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Functional Genomics

The Functional Genomics Capability provides the tools and expertise for unbiased, systematic, high-throughput gain-of-function and loss-of-function screens in human and mouse cells. In collaboration with our MHTP Platforms network, we deliver a complete gene discovery and characterisation service.

Our pooled library screens take advantage of the latest in CRISPR-Cas9 technology (CRISPRc, CRISPRi, CRISPRa) and ORF libraries. Pooled screening is faster, less labour-intensive and more cost-effective than array-based screens, making functional genomics more accessible for researchers investigating questions ranging from fundamental biology through to addressing clinical need. We have validated genome-wide libraries available or we can work with you to custom-design libraries that suit
your research needs.