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Publications

 

MHTP Medical Genomics Facility capabilities, services and technical expertise have facilitated numerous publications in a broad range of disciplines. Researchers have cited and/or confirmed the use of our services in helping to generate the following peer reviewed publications:

The Gandel Charitable Trust Sequencing Centre - Sanger Sequencing and qPCR Publications:

2016

Transcriptomic analysis of stage 1 versus advanced adult granulosa cell tumors - Alexiadis M, Chu S, Leung D, Gould JA, Jobling T, Fuller PJ. Oncotarget 2016 7(12):14207-14219. Link to Article

Cre-dependent DNA recombination activates a STING-dependent innate immune response - Pépin G, Ferrand J, Höning K, Jayasekara WS, Cain JE, Behlke MA, Gough DJ, Williams BR, Hornung V, Gantier MP. Nucleic Acids Res. 2016 May 10. pii: gkw405. [Epub ahead of print] PubMed PMID: 27166376. Link to Article

2015:

IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction - Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. Nat Immunol. 2015 Apr;16(4):354-65. Link to Article

The Combination of ISCOMATRIX Adjuvant and TLR Agonists Induces Regression of Established Solid Tumors In Vivo - Silva A, Mount A, Krstevska K, Pejoski D, Hardy MP, Owczarek C, Scotney P, Maraskovsky E, Baz Morelli A. J Immunol. 2015 Mar 1;194(5):2199-207. Link to Article

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity - Takizawa I, Lawrence MG, Balanathan P, Rebello R, Pearson HB, Garg E, Pedersen J, Pouliot N, Nadon R, Watt MJ, Taylor RA, Humbert P, Topisirovic I, Larsson O, Risbridger GP, Furic L. Oncotarget. 2015 Jan 20;6(2):604-16. Link to Article

Effects of estrogens on adipokines and glucose homeostasis in female aromatase knockout mice -Van Sinderen ML, Steinberg GR, Jørgensen SB, Honeyman J, Chow JD, Herridge KA, Winship AL, Dimitriadis E, Jones MEE, Simpson ER, Boon WC. PLoS One 2015 10(8):e0136143. Link to Article

Adrenal Cushing’s syndrome in pregnancy: clinical and molecular characterisation of a case - Trinh A, Chan I, Alexiadis M, Pell M, Kumar B, Fuller PJ. Obstetric Medicine 2015 9:43-45. Link to Article

Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult - Bienvenu LA, Reichelt ME, Morgan J, Fletcher EK, Bell JR, Rickard AJ, Delbridge LM, Young MJ. Hypertension 2015 66(5):970-977. Link to Article

Somatic mutations of FOXE1 in papillary thyroid cancer - Mond M, Bullock M, Yao Y, Clifton-Bligh RJ, Gilfillan C, Fuller PJ. Thyroid 2015 25:904-910. Link to Article

Aldosterone-mediated renal sodium transport requires intact mineralocorticoid receptor DNA-binding in the mouse - Cole TJ, Terella L, Morgan J, Alexiadis M, Yao YZ, Enriori P, Young MJ, Fuller PJ. Endocrinology 2015 156(8):2958-2968. Link to Article

Gemin4 functions as a coregulator of the mineralocorticoid receptor - Yang J, Fuller PJ, Morgan J, Shibata H, McDonnell D, Clyne CD, Young MJ. Jnl of Mol Endo. 2015 54:149-160. Link to Article

2014:

Use of phage display to identify novel mineralocorticoid receptor-interacting proteins - Yang J, Fuller PJ, Morgan J, Shibata H, McDonnell DP, Clyne CD, Young MJ. Molecular Endocrinology. 2014, 28(9):1571-84. Link to Article

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody - Broughton SE, Hercus TR, Hardy MP, McClure BJ, Nero TL, Dottore M, Huynh H, Braley H, Barry EF, Kan WL, Dhagat U, Scotney P, Hartman D, Busfield SJ, Owczarek CM, Nash AD, Wilson NJ, Parker MW, Lopez AF. Cell Rep. 2014 Jul 24;8(2):410-9. Link to Article

Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer - Soh CL, McNeil K, Owczarek CM, Hardy MP, Fabri LJ, Pearse M, Delaine CA, Forbes BE. Br J Cancer. 2014 Jun 10;110(12):2855-64. Link to Article

Identification of potent antagonist antibodies against mouse IL-13R?1 using novel bioassays - Edwards KM, Huynh H, Prasad R, McDonald A, Hardy MP, Scotney P, Owczarek CM, Busfield SJ, Panousis C, Wilson NJ. J Immunol Methods. 2014 May;407:48-57. Link to Article

Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock - Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, Owczarek CM, Hertzog PJ. J Immunol. 2014 May 1;192(9):4425-35. Link to Article

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362 - Broughton SE, Hercus TR, Nero TL, Dhagat U, Owczarek CM, Hardy MP, Fabri LJ, Scotney PD, Nash AD, Wilson NJ, Lopez AF, Parker MW. Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):358-61. Link to Article

A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk - Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T. Sci Transl Med. 2014 Feb 5;6(222):222ra17. Link to Article

Nuclear receptor expression in human differentiated thyroid tumors - Mond M, Alexiadis M, Eriksson N, Davis M J, Muscat GEO, Fuller PJ, and Gilfillan C. Thyroid. June 2014, 24(6): 1000-1011. Link to Article

Mutation profile of differentiated thyroid tumors in an Australian urban population - Mond, M, Alexiadis, M, Fuller, PJ and Gilfillan, C. (2014) Internal Medicine Journal, 44: 727–734.  Link to Article

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8 - Sarvestani ST, Tate MD, Moffat JM, Jacobi AM, Behlke MA, Miller AR, Beckham SA, McCoy CE, Chen W, Mintern JD, O'Keeffe M, John M, Williams BR, Gantier MP. J Virol. 2014 Jan;88(2):799-810. Link to Article

Presence of HIV drug resistance in antiretroviral therapy-naive and -experienced patients from Papua New Guinea - Gare J, Ryan CE, David M, Timbi D, Kaima P, Kombati Z, Imara U, Kelly-Hanku A, Siba PM, Crowe SM, Hearps AC. Antimicrob. Chemother. 2014 Epub 2014 Apr 9. Link to Article

Galectin-7 is important for normal uterine repair following menstruation - Evans J, Yap J, Gamage T, Salamonsen L, Dimitriadis E, Menkhorst E. Mol Hum Reprod. 2014 Aug;20(8):787-98. Link to Article

IL-32 promotes angiogenesis - Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF. J Immunol. 2014 Jan 15;192(2):589-602. Link to Article

Differential permeability of the blood-testis barrier during re-initiation of spermatogenesis in adult male rats - Haverfield JT, Meachem SJ, Nicholls PK, Rainczuk KE, Simpson ER, Stanton PG. Endocrinology. 2014 Mar;155(3):1131-44. Link to Article

2013:

Structural basis of a novel Interferon β signaling axis mediated via the Ifnar1 receptor -  NA de Weerd, JP Vivian, T Nguyen, NE Mangan, JA Gould, S Noppert, L Zaker-Tabrizi, KY Fung, T Beddoe, HH Reid, J Rossjohn, PJ Hertzog. Nature Immunology. 2013; 14, 901-7. Link to Article

Interferon epsilon is a novel, innate cytokine that protects the reproductive tract from viral and bacterial infection - KY Fung, NE Mangan, H Cumming, JC Horvat, JR Mayall, S Stifter, NA de Weerd, LC Roisman, J Rossjohn, S Robertson, J Schjenken, BS Parker, C Gargett, HPT Nguyen, DJ Carr, PM Hansbro, PJ Hertzog. Science. 2013; 339, 1088-92. Link to Article

The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease - Wu D, Hu Y, Tong S, Williams BR, Smyth GK, Gantier MP. RNA. 2013 Jul;19(7):876-88. doi: 10.1261/rna.035055.112. Epub 2013 May 24. Link to Article

Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation - Nicholls PK, Harrison CA, Rainczuk KE, Vogl AW, Stanton PG. Molecular and Cellular Endocrinology. 2013; 377(1–2): 33–43. Link to Article

Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats - Spanevello MD, Tajouri SI, Mirciov C, Kurniawan N, Pearse MJ, Fabri LJ,
Owczarek CM, Hardy MP, Bradford RA, Ramunno ML, Turnley AM, Ruitenberg MJ, Boyd AW, Bartlett PF. J Neurotrauma. 2013 Jun 15;30(12):1023-34. Link to Article

A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium - Du M, Young J, De Asis M, Cipollone J, Roskelley C, Takai Y, Nicholls PK, Stanton PG, Deng W, Finlay BB, Vogl AW. Biol Reprod. 2013 Mar 14;88(3):60. Link to Article

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens - Winnall WR, Wu H, Sarraj MA, Rogers PA, de Kretser DM, Girling JE, Hedger MP. Reprod Fertil Dev. 2013;25(3):570-80. Link to Article

Effects of TGFbeta2 on wild-type and Tgfbr3 knockout mouse fetal testis - Sarraj MA, Escalona RM, Western P, Findlay JK, Stenvers KL. Biol Reprod. 2013 Mar 14;88(3):66. Link to Article

Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium - Wilkinson SE, Furic L, Buchanan G, Larsson O, Pedersen J, Frydenberg M, Risbridger GP, Taylor RA. Prostate. 2013 Dec;73(16):1810-23. Link to Article

Mechanical ventilation injury and repair in extremely and very preterm lungs - Brew N, Hooper SB, Zahra V, Wallace M, Harding R. PLoS One. 2013 May 21;8(5):e63905. Link to Article

Selective regulation of p38β protein and signaling by integrin-linked kinase mediates bladder cancer cell migration - Yu L, Yuan X, Wang D, Barakat B, Williams ED, Hannigan GE. Oncogene. 2014 Feb 6;33(6):690-701. Link to Article

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling - Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, Martelotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE. EMBO Rep. 2013 Sep;14(9):837-44. Link to Article

2012:

A miR-19 regulon that controls NF-κB signaling - Gantier MP, Stunden HJ, McCoy CE, Behlke MA, Wang D, Kaparakis-Liaskos M, Sarvestani ST, Yang YH, Xu D, Corr SC, Morand EF, Williams BR. Nucleic Acids Res. 2012 Sep;40(16):8048-58. Link to Article

Prostaglandins mediate the fetal pulmonary response to intrauterine inflammation - Westover AJ, Hooper SB, Wallace MJ, Moss TJ. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L664-78. Link to Article

Activin signaling regulates Sertoli cell differentiation and function - Nicholls PK, Stanton PG, Chen JL, Olcorn JS, Haverfield JT, Qian H, Walton KL, Gregorevic P, Harrison CA. Endocrinology. 2012 Dec;153(12):6065-77. Link to Article

Lentiviral transduction of rat Sertoli cells as a means to modify gene expression - Nicholls PK, Stanton PG, Rainczuk KE, Qian H, Gregorevic P, Harrison CA. Spermatogenesis. 2012 Oct 1;2(4):279-284. Link to Article

2011:

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation - Gantier MP, McCoy CE, Rusinova I, Saulep D, Wang D, Xu D, Irving AT, Behlke MA, Hertzog PJ, Mackay F, Williams BR. Nucleic Acids Res. 2011 Jul;39(13):5692-703. Link to Article

Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis - Mendis SH, Meachem SJ, Sarraj MA, Loveland KL. Biol Reprod. 2011 Feb;84(2):379-91. Link to Article

Betaglycan is required for the establishment of nephron endowment in the mouse - Walker KA, Sims-Lucas S, Caruana G, Cullen-McEwen L, Li J, Sarraj MA, Bertram JF, Stenvers KL. PLoS One. 2011 Apr 18;6(4):e18723. Link to Article

Estrogen-Dependent Gene Expression in the Mouse Ovary - Liew SH, Sarraj MA, Drummond AE, Findlay JK (2011). PLoS ONE 6(2): e14672. Link to Article

Extracellular matrix dynamics in scar-free endometrial repair: perspectives from mouse in vivo and human in vitro studies - Evans J, Kaitu'u-Lino T, Salamonsen LA. Biol Reprod. 2011 Sep;85(3):511-23. Link to Article

Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display - Yang J, Chang CY, Safi R, Morgan J, McDonnell DP, Fuller PJ, Clyne CD, Young MJ. Mol Endocrinol. 2011 Jan;25(1):32-43. Link to Article

2010:

Hormonal regulation of sertoli cell micro-RNAs at spermiation - Nicholls PK, Harrison CA, Walton KL, McLachlan RI, O'Donnell L, Stanton PG. Endocrinology. 2011 Apr;152(4):1670-83. Link to Article

 

ACRF Centre for Cancer Genomic Medicine - NextGen Sequencing and Microarray Publications:

2016:

Role of miRNAs and alternative mRNA 3′-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy - Soetanto R, Hynes CJ, Patel HR, Humphreys DT, Evers M, Duan G, Parker BJ, Archer SK, Clancy JL, Graham RM, Beilharz TH, Smith NJ, Preiss T . Biochim Biophys Acta. 2016 Mar 24; 1859(5):744-756. Link to Article

The relationship between mitochondrial DNA haplotype and the reproductive capacity of domestic pigs (Sus scrofa domesticus) - Tsai TS, Rajasekar S, St. John JC. BMC Genetics. 2016;17(1):67. Link to Article

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency - Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St. John JC. Scientific Reports. 2016; 6:23229. Link to Article

Segregation of naturally occurring mitochondrial DNA variants in a mini-pig model - Cagnone G, Tsai T, Srirattana K, Rossello F, Powel DR, Trounce IA, Rohrer G, Cree L, St. John JC. Genetics 2016; 202:931–944. Link to Article

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis - Lee W, Cain J, Cuddihy A, Johnson J, Dickinson A, Yeung KY, Kumar B, Johns TG, Watkins DN, Spencer A, St. John JC. Cell Death Discovery 2016; 2:16016. Link to Article

Deletion of the complex I subunit NDUFS4 adversely modulates cellular differentiation -Johnson J, Lee W, Frazier AE, Vaghjiani V, Rodriguez AL, Cagnone GL, McKenzie M, White SJ, Nisbet DR, Thorburn DR, St. John JC. Stem Cells and Development 2016; 1;25(3):239-50. Link to Article

Analysis of Mitochondrial DNA Copy Number and Its Regulation Through DNA Methylation of POLGA Mitochondrial DNA - Sun X, Lee W, Vaghjiani V, St. John JC. Methods in Molecular Biology. 2016; 1351:131-41. Link to Article

Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells - Cagnone G, Vaghjiani V, Lee W, Sun C, Johnson J, Yeung K, St. John JC. Methods in Molecular Biology. 2016; 1357:231-67. Link to Article

2015:

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors - Sarvestani ST, Stunden HJ, Behlke MA, Forster SC, McCoy CE, Tate MD, Ferrand J, Lennox KA, Latz E, Williams BR, Gantier MP. Nucleic Acids Res. 2015 Jan;43(2):1177-88. Link to Article

IL-10 regulates Aicda expression through miR-155 - Fairfax KA, Gantier MP, Mackay F, Williams BR, McCoy CE. J Leukoc Biol. 2015 Jan; 97(1):71-8. Link to Article

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis - Cottle DL, Ursino GM, Ip SC, Jones LK, Ditommaso T, Hacking DF, Mangan NE, Mellett NA, Henley KJ, Sviridov D, Nold-Petry CA, Nold MF, Meikle PJ, Kile BT, Smyth IM. Hum Mol Genet. 2015 Jan 15; 24(2):436-49. Link to Article

Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism - Meex RC, Hoy AJ, Morris A, Brown RD, Lo JC, Burke M, Goode RJ, Kingwell BA, Kraakman MJ, Febbraio MA, Greve JW, Rensen SS, Molloy MP, Lancaster GI, Bruce CR, Watt MJ. Cell Metab. 2015 22: 1078-89. Link to Article

Integration of Posttranscriptional Gene Networks into Metabolic Adaptation and Biofilm Maturation in Candida albicans - Verma-Gaur J, Qu Y, Harrison P, Quenault T, Lo T, Celik N, Bellousoff M, Tzyganov K, Powell D, Beilharz TH, and Traven A. PLoS Genet. 2015 Oct 16; 11(10):e1005590 Link to Article

POS-1 promotes endo-mesoderm development by inhibiting the cytoplasmic polyadenylation of neg-1 mRNA - Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC. Dev. Cell 2015. 34 (1), 108-118. Link to Article

PAT-seq: A method to study the integration of 3' UTR dynamics with gene-expression in the eukaryotic transcriptome - Harrison P, Powell D, Clancy J, Preiss T, Boag P, Traven A, Seemann T, Beilharz TH. RNA 2015 21 (8), 1502-1510. Link to Article

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors - Sarvestani ST, Stunden HJ, Behlke MA, Forster SC, McCoy CE, Tate MD, Ferrand J, Lennox KA, Latz E, Williams BR, Gantier MP. Nucleic Acids Res. 2015 Jan;43(2):1177-88. Link to Article

Differences in mitochondrial DNA inheritance and function align with body conformation in genetically lean and fat sheep - Henry BA, Loughnan R, Hickford J, Young, IR, St. John J, Clarke IJ. Journal of Animal Science 2015; 93(5):2083-2093. Link to Article

Mitochondrial dysfunction in oocytes of obese mothers; transmission to offspring and reversal by pharmacological ER-stress inhibitors - Wu LL, Russell DL, Wong SL, Chen M, Tsai T, St. John JC, Norman RJ, Febbraio MA, Carroll J, Robker RL. Development 2015; 142(4):681-691. Link to Article

Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells - Lee W, Kelly RDW, Yeung KY, Cagnone G, McKenzie M, St John JC. Methods in Molecular Biology 2015; 1330:219-52. Link to Article

2014:

A global virulence regulator in Acinetobacter baumannii and its control of the phenylacetic acid catabolic pathway - Cerqueira GM, Kostoulias X, Khoo C, Aibinu I, Qu Y, Traven A, Peleg AY. J Infect Dis. 2014 Jul 1;210(1):46-55. Link to Article

Functional evaluation of ES-somatic cell hybrids in vitro and in vivo - Sumer H, Kim Kitai, Liu J, Ng K, Daley GQ, Verma PJ. Cellular Reprogramming. 2014; 16(3):167-174. Link to Article

Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell Lines - van der Zwan YG, Rijlaarsdam MA, Rossello FJ, J. Notini AJ, de Boer S, Watkins DN, Gillis AJM, Dorssers LCJ, White SJ, Looijenga LHJ.PLoS One. 2014; 9(6): e98330. Link to Article

The identification of mitochondrial DNA variants in glioblastoma multiforme - Ka Yu Yeung, Adam Dickinson, Jacqueline F Donoghue, Galina Polekhina, Stefan J White, Dimitris K Grammatopoulos, Matthew McKenzie, Terrance G Johns and Justin C St John. Acta Neuropathologica Communications 2014, 2:1. Link to Article

Integration-Free Human Induced Pluripotent Stem Cells from Type 1 Diabetes Patient Skin Fibroblasts Show Upregulations of Pancreas-Specific microRNAs - Liu, J, Joglekar MV, Sumer H, Hardikar AA, Teede H, Verma PJ. Cell Medicine. May 2, 2014. DOI:dx.doi.org/10.3727/215517914X681785. Link to Article

Age-related changes in tissue macrophages precede cardiac functional impairment - Pinto AR, Godwin JW, Chandran A, Hersey L, Ilinykh A, Debuque R, Wang L, Rosenthal NA. Aging (Albany NY). 2014 May;6(5):399-413. Link to Article

Use of phage display to identify novel mineralocorticoid receptor-interacting proteins - Yang J, Fuller PJ, Morgan J, Shibata H, McDonnell DP, Clyne CD, Young MJ. Mol Endocrinol. 2014 Sep;28(9):1571-84. Link to Article

Estradiol regulates Tumor Necrosis Factor-α expression and secretion in Estrogen Receptor positive breast cancer cells - To SQ, Cheung V, Lazarus KA, Knower KC, Clyne CD. Mol Cell Endocrinol. 2014 Jul 5;394(1-2):21-28. Link to Article

Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-β - Lazarus KA, Brown KA, Young MJ, Zhao Z, Coulson RS, Chand AL, Clyne CD. Endocrinology. 2014 May;155(5):1606-17. Link to Article

Nelumal A, the active principle of Ligularia nelumbifolia, is a novel aromatase inhibitor. Epifano F, Genovese S, Fiorito S, Nde CM, Clyne C. Nat Prod Commun. 2014 Jun;9(6):823-4. Link to Article

Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair - Furtado MB, Costa MW, Pranoto EMA, Salimova E, Pinto AR, Lam NT, Park A, Snider P, Chandran A, Harvey RP, Boyd R, Conway SJ, Pearson JT, Kaye DM, Rosenthal N. Circulation Research. March 2014. Link to Article

The identification of mitochondrial DNA variants in glioblastoma multiforme - Yeung KY, Dickinson A, Donoghue JF, Polekhina G, White SJ, Grammatopoulos DK, McKenzie M, Johns TG, St. John JC. Acta Neuropathologica Communications 2014; 2;2:1. Link to Article

Damaging legacy; maternal cigarette smoking has long-term consequences for male offspring fertility - S Sobinoff AP, Sutherland JM, Beckett EL, Stanger SJ, Johnson R, Jarnicki AG, McCluskey A, St. John JC, Hansbro PM, McLaughlin EA. Human Reproduction 2014; 29(12):2719-2735. Link to Article

Capture of somatic mtDNA point mutations with severe effects on oxidative phosphorylation in synaptosome cybrid clones from human brain - McKenzie M, Chiotis M, Hroudova J, Lopez Sanchez MIG, Lim SC, Cook MJ, McKelvie P, Cotton RGH, Murphy M, St. John JC, Trounce IA. Human Mutation 2014; 35(12):1476-1484. Link to Article

2013:

Role of epigenetics in the etiology of germ cell cancer - Van Der Zwan YG, Stoop H, Rossello F, White SJ, Looijenga LH. Int J Dev Biol. 2013;57(2-4):299-308. Link to Article

Next-generation sequence analysis of cancer xenograft models - Rossello FJ, Tothill RW, Britt K, Marini KD, Falzon J, Thomas DM, Peacock CD, Marchionni L, Li J, Bennett S, Tantoso E, Brown T, Chan P, Martelotto LG, Watkins DN. PLoS One. 2013 Sep 26;8(9):e74432. Link to Article

Distinct nuclear receptor expression in stroma adjacent to breast tumors - Knower KC, Chand AL, Eriksson N, Takagi K, Miki Y, Sasano H, Visvader JE, Lindeman GJ, Funder JW, Fuller PJ, Simpson ER, Tilley WD, Leedman PJ, Graham J, Muscat GE, Clarke CL, Clyne CD. Breast Cancer Res Treat. 2013 Nov;142(1):211-23. Link to Article

Oestradiol reduces liver receptor homolog-1 mRNA transcript stability in breast cancer cell lines - Lazarus KA, Zhao Z, Knower KC, To SQ, Chand AL, Clyne CD. Biochem Biophys Res Commun. 2013 Aug 30;438(3):533-9. Link to Article

Involvement of early growth response factors in TNFα-induced aromatase expression in breast adipose - To SQ, Simpson ER, Knower KC, Clyne CD. Breast Cancer Res Treat. 2013 Feb;138(1):193-203. Link to Article

NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression - To SQ, Knower KC, Clyne CD. Biochem Biophys Res Commun. 2013 Mar 29;433(1):96-101. Link to Article

Liver receptor homologue-1 expression in ovarian epithelial and granulosa cell tumours - Chand AL, Pathirage N, Lazarus K, Chu S, Drummond AE, Fuller PJ, Clyne CD. Steroids. 2013 Jul;78(7):700-6. Link to Article

2012:

Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer - To SQ, Takagi K, Miki Y, Suzuki K, Abe E, Yang Y, Sasano H, Simpson ER, Knower KC, Clyne CD. J Steroid Biochem Mol Biol. 2012 Nov;132(3-5):331-8. Link to Article

The Orphan Nuclear Receptor LRH-1 and ERα Activate GREB1 Expression to Induce Breast Cancer Cell Proliferation - Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD. PLoS One. February 16, 2012. Link to Article

Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblasts - Knower KC, To SQ, Takagi K, Miki Y, Sasano H, Simpson ER, Clyne CD. Breast Cancer Res Treat. 2012 Apr;132(2):765-71. Link to Article

In vitro estrogenic activity of two major compounds from the stem bark of Erythrina lysistemon (Fabaceae) - Magne Nde CB, Njamen D, Tanee Fomum S, Wandji J, Simpson E, Clyne C, Vollmer G. Eur J Pharmacol. 2012 Jan 15;674(2-3):87-94. Link to Article

2011:

Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts - Liu J, Ashton MP, Sumer H, O'Bryan MK, Brodnicki, TC and Verma PJ. Diabetes. May 2011; 60(5): 1393–1398. Apr 23, 2011. Link to Article

Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts - Chand AL, Herridge KA, Howard TL, Simpson ER, Clyne CD. Steroids. 2011 Jul;76(8):741-4. Link to Article

 

Single Cell Genomics Centre - A Fluidigm Centre of Excellence:

2016:

Cardiac tissue injury and remodeling is dependent upon MR regulation of activation pathways in cardiac tissue macrophages - Shen JZ, Morgan J, Tesch GH, Rickard AJ, Chrissobolis S, Drummond GR, Fuller PJ, Young MJ. Endocrinology. 2016 Jun 2:en20161040. [Epub ahead of print]. Link to Article

A versatile strategy for isolating a highly enriched population of intestinal stem cells - Nefzger CM, Jardé T, Rossello FJ, Horvay K, Knaupp AS, Powell DR, Chen J, Abud HE, Polo JM. Stem Cell Reports 2016 Mar 8; 6(3):321–329. Link to Article

2015:

Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus - Jones SA, Toh AE J, Odobasic D, Oudin M-A V, Cheng Q, Lee JP W, et al. Ann Rheum Dis. 2015 75(4):739-47. Link to Article

GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation - Jones SA, Perera DN, Fan H, Russ BE, Harris J & Morand EF. Journal of Autoimmunity. 2015  61, 73–80. Link to Article